Radiation-induced changes to bone composition extend beyond periosteal bone

Radiation-induced periosteal osteosarcoma

Radiation-induced sarcomas are a well-recognized late complication of radiation therapy. We present a rare case of a periosteal osteosarcoma of the femur developing 10 years after radiation treatment for a soft tissue sarcoma to highlight the clinical and radiological features of this rare complication of therapy and to describe its management.

Niacin Exacerbates Methyl Prednisolone-Induced Bone Changes in Growing Rats

Positive role of niacin on serum lipid profile of rats treated with glucocorticoids (GCs) has been reported. This study aims to evaluate effect of niacin on bone changes in GC-induced dyslipidemic rats. A number of 28 growing rats divided into four groups and treated as control, Methyl prednisolone (MP) group (3.5 mg/kg five days a week, SC); MPN group (MP + niacin 200 mg/kg/day orally) and MPA...

Bone-composition imaging using coherent-scatter computed tomography: assessing bone health beyond bone mineral density.

Quantitative analysis of bone composition is necessary for the accurate diagnosis and monitoring of metabolic bone diseases. Accurate assessment of the bone mineralization state is the first requirement for a comprehensive analysis. In diagnostic imaging, x-ray coherent scatter depends upon the molecular structure of tissues. Coherent-scatter computed tomography (CSCT) exploits this feature to ...

Bioengineered periosteal progenitor cell sheets to enhance tendon-bone healing in a bone tunnel.

BACKGROUND Tendon-bone tunnel healing is crucial for long term success in anterior cruciate ligament (ACL) reconstruction. The periosteum contains osteochondral progenitor cells that can differentiate into osteoblasts and chondroblasts during tendon-bone healing. We developed a scaffold-free method using polymerized fibrin-coated dishes to make functional periosteal progenitor cell (PPC) sheets...

Evidence Report: Risk of Bone Fracture due to Spaceflight- induced Changes to Bone